Hospitals need to use non AMR causing anti microbial solutions, like BioProtect US

A trip to hospital can play havoc with your gut bacteria. People treated for several days in an intensive care unit had their stomachs quickly colonised by harmful pathogens, tests show. Healthier gut microbes were pushed out – a shift that may have long-term effects after someone is discharged.

Heavy use of broad-spectrum antibiotics, feeding people through a tube and using a ventilator to help them breathe could all contribute to the effect, say the team who carried out the study.

“It’s quite disconcerting,” says Mark Pallen, a microbial genomics researcher at the Quadram Institute, UK, who led the research. “I was surprised. I mean, I suspected that something like this was going on, but I was quite taken aback at the scale of the changes.”

To assess the impact of intensive care treatment on the gut microbiome, the team tracked 24 people admitted for trauma, heart attacks, cancer and other emergencies to Queen Elizabeth Hospital Birmingham, UK, over a 10-month period.

The gut is normally home to a rich and versatile set of microorganisms, says Pallen. “Whereas in these patients, we are seeing all that diversity collapsing down to domination of the gut microbiota by a single organism occurring at a very high abundance.”

Most frequently, the researchers found that patients’ guts were dominated by Enterococcus faeciuma common bacterial pathogen. That is a problem because this microbe can spread from the gut and damage other parts of the body, including the lungs. If it reaches the bloodstream, it can be fatal.

While the priority in intensive care is always to save lives, Wiersinga says medics could do more to minimise disruption to gut bacteria. “If you need to give antibiotics then give them. But think about which antibiotic, for how long and if you can stop earlier.”

Journal reference: Microbial GenomicsDOI: 10.1099/mgen.0.000293

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